fulab.johnshopkins.eduFu Lab
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Fulab.johnshopkins.edu is a subdomain of johnshopkins.edu,
which was created on 1996-10-18,making it 28 years ago.
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Contact US • Physiology • Johns Hopkins Overview Projects Publications Lab Members Job Openings Overview Zinc transporters regulate subcellular zinc distributions to ensure proper metalation of a wide range of cellular proteins that amount to about one quarter of a mammalian proteome. For example, a human zinc transporter (ZnT8) enriches zinc in the insulin-containing vesicles of pancreatic beta cells where zinc is required for insulin dense core formation. The vesicular zinc is co-released with insulin in response to glucose stimulations, and serves as a feedback signal molecule that regulates insulin secretion and clearance. Our research is to understand which step in zinc transport may be modulated and how. The physicochemical principles governing zinc transport have been investigated using an integrated approach of membrane biochemistry, biophysics and structural biology. Parallel cell biology and proteomic approaches are used to understand how these physicochemical principles are applied to mammalian zinc transporters and integrated to physiology of pancreatic beta cells. Latest News Visualizing the kinetic power stroke that drives proton-coupled Zn(II) transport. Nature (2014), in press. © 2014 . All rights...
fulab.johnshopkins.edu Whois
This Registry database contains ONLY .EDU domains. The data in the EDUCAUSE Whois database is provided by EDUCAUSE for information purposes in order to assist in the process of obtaining information about or related to .edu domain registration records. The EDUCAUSE Whois database is authoritative for the .EDU domain. A Web interface for the .EDU EDUCAUSE Whois Server is available at: http://whois.educause.edu By submitting a Whois query, you agree that this information will not be used to allow, enable, or otherwise support the transmission of unsolicited commercial advertising or solicitations via e-mail. The use of electronic processes to harvest information from this server is generally prohibited except as reasonably necessary to register or modify .edu domain names. Domain Name: JOHNSHOPKINS.EDU Johns Hopkins University Office of Information Technology 615 N. Wolfe St. Baltimore, MD 21205-2179 USA Domain Admin Johns Hopkins University Office of Information Technology 615 N. Wolfe St. Baltimore, MD 21205-2179 USA +1.6672086120 hostmaster@jhmi.edu Domain Admin Johns Hopkins University Office of Information Technology 615 N. Wolfe St. Baltimore, MD 21205-2179 USA +1.6672086120 hostmaster@jhmi.edu ENS1.JHU.EDU ENS1.JHMI.EDU Domain record activated: 18-Oct-1996 Domain record last updated: 15-Aug-2023 Domain expires: 31-Jul-2024